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  Polish Academy of Sciences
  Institute of Immunology and Experimental Therapy
  Centre of Excellence since October 2002

Bacteriophage research and therapy


Our Institute's publications:
  1. Bacteriophages and cancer, P.Budynek, K.Dąbrowska, G.Skaradziński, A.Górski, Archives of Microbiology 2010 (in press)
  2. Enzybiotics and their potential applications in medicine, J.Borysowski, A.Górski, In: Enzybiotics Enzymes as drugs and therapeutics, pp 1-26. TG Villa, P. Veiga-Crespo, eds., Wiley & Sons, 2010.
  3. Anti-staphylococcal lytic enzymes, J.Borysowski, A.Górski, In: Enzybiotics Enzymes as drugs and therapeutics, pp 149-172. TG Villa, P. Veiga-Crespo, eds., Wiley & Sons, 2010.
  4. Pathogen eradication by phage therapy in patients with chronic bacterial prostatitis, S.Letkiewicz, R.Międzybrodzki, M.Kłak, B.Weber-Dąbrowska, A.Górski, 25th Annual European Association of Urology Congress, Barcelona, 16-20 April, 2010
  5. Prophylactic effect of bacteriophages on mice subjected to chemotherapy-induced immunosuppression and bone marrow transplant upon infection with Staphylococcus aureus, Michał Zimecki, Jolanta Artym, Maja Kocięba, Beata Weber-Dąbrowska, Jan Borysowski, Andrzej Górski, Med Microbiol Immunol (in press)
  6. The effects of staphylococcal bacteriophage lysates on cancer cells in vitro, K.Dąbrowska, G.Szkaradziński, A.Kurzępa, B.Owczarek, M.Żaczek, B.Weber-Dąbrowska, J.Wietrzyk, M.Maciejewska, P.Budynek, A.Górski, Clin Exp Med 2010,10,81-85
    http://www.springerlink.com/content/740262658m04n256/
  7. Effects of prophylactic administration of bacteriophages to immunosuppressed mice infected with Staphylococcus aureus, M. Zimecki, J. Artym, M., B. Weber-Dąbrowska, J. Borysowski and A.Górski, BMC Microbiology 2009, 9:169
    http://www.biomedcentral.com/1471-2180/9/169
  8. Bacteriophage therapy for treatment of infections, A.Górski, R.Międzybrodzki, J.Borysowski, B. Weber-Dąbrowska, M. Łobocka , W. Fortuna, S. Letkiewicz, M. Zimecki, G. Filby, Curr Opin Invest Drugs 2009,10,766-74
  9. Antitumor effect of combined treatment of mice with cytostatic agents and bacteriophage T4, Szczaurska-Nowak K, Dabrowska K, Celka M, Kurzepa A, Nevozhay D, Wietrzyk J, Switala-Jelen K, Syper D, Pozniak G, Opolski A, Górski A, Radzikowski C, Anticancer Res. 2009 Jun;29(6):2361-70
  10. Eradication of Enterococcus faecalis by phage therapy in chronic prostatitis, S.Letkiewicz, R.Międzybrodzki, W.Fortuna, B.Weber-Dąbrowska, A.Górski, Folia Microbiol. 2009,54(5),457–461
    http://www.springerlink.com/content/134w262258374308/
  11. Fusion to cell-penetrating peptides will enable lytic enzymes to kill intracellular bacteria, Borysowski J., Górski, A., Medical Hypotheses. 2010,74,164-6
  12. A retrospective analysis of changes in inflammatory markers in patients treated with bacterial viruses, Międzybrodzki R., Fortuna W., Weber-Dąbrowska B., Górski, A., Clin.Exp.Med. 2009,9,303-12
  13. The Effect of Bacteriophages T4 and HAP1 on In Vitro Melanoma Migration, Dąbrowska K., Skaradzinski G., Jończyk P., Aneta Kurzępa A., Wietrzyk J., Owczarek B., Żaczek M., Świtała-Jeleń K., Boratyński J., Poźniak G., Maciejewska M., Górski A., BMC Microbiology 2009,9:13
    http://www.biomedcentral.com/1471-2180/9/13/abstract
  14. Bacteriophage interactions with phagocytes and their potential significance in experimental therapy, Kurzępa A., Dąbrowska K., Skaradziński G., Górski A., Clin Exp Med 2009,9,93-100
  15. Eighty years of phage therapy in Poland: Past, present, and future, Górski A., Weber-Dąbrowska B., Międzybrodzki R., Fortuna W., Dąbrowska K., Letkiewicz S., Edinburgh International Phage Conference, 26-29 July 2008, abstracts p. 15
  16. T4 phage does not induce a strong oxydative burst in peripheral blood neutrophils in mice, Borysowski J., Wierzbicki P., Kłosowska D., Przerwa A., Górski A., Edinburgh International Phage Conference, 26-29 July 2008, abstracts p. 75
  17. Pathogen eradication by phage therapy in patients with chronic bacterial prostatitis, Międzybrodzki R., Letkiewicz S., Górski A., Edinburgh International Phage Conference, 26-29 July 2008, abstracts p. 79
  18. Molecular modification of T4 bacteriophage proteins and its potential application, A. Kurzępa, K. Dąbrowska, K. Świtała-Jeleń, A. Górski, Folia Microbiologica, 2009;54,5-15
  19. The potential of phage therapy in bacterial infections of the eye , Andrzej Górski, Magdalena Targońska, Jan Borysowski, Beata Weber-Dąbrowska, Ophthalmologica 2009;223:162-165
  20. The effect of bacteriophages T4 and HAP1 on in vitro melanoma migration,
    EMBO Meeting: Cellular Signaling and Molecular Medicine, May 29 – Jun 4, 2008, Cavtat/Dubrovnik, Croatia
  21. Bacteriophage therapy in children: facts and prospects, Fortuna W., Międzybrodzki R., Weber-Dąbrowska B., Górski A., Med Sci Monit 2008,14,126-132
  22. Is phage therapy acceptable in the immunocompromised host?, J.Borysowski, A.Górski, Int J Infect Dis 2008,12,466-471
  23. Bacteriophages support anti-tumor response initiated by DC-based vaccine against murine transplantable colon carcinoma, Pajtasz-Piasecka E., Rossowska J., Dus D., Weber-Dabrowska B., Zablocka A., Górski A., Immunology Letters 2008,116,24-32
  24. Bacteriophages decrease activity of NF-kappa B induced in human mononuclear cells by human herpesvirus-1, WA Gorczyca, M.Mitkiewicz, J.Siednienko, E.Kurowska, E.Piasecki, B.Weber-Dąbrowska, A.Górski, In: 13th International Congress of Immunology, Brazil, August 2007. Eds: J.Kalil, E.Cunha-Neto, L.V.Rizzo, Medimond, 2007, p.73-77
  25. Bacteriophage preparation inhibition of reactive oxygen species generation by endotoxin - stimulated polymorphonuclear leukocytes, Międzybrodzki, K.Świtała-Jeleń, W.Fortuna, B.Weber-Dąbrowska, A.Przerwa, M.Łusiak-Szelachowska, K.Dąbrowska, J.Boratyński, D.Syper, G.Późniak, Cz.Ługowski, A.Górski, Virus Res. 2008,131,233-242
  26. Phage therapy of staphylococcal infections (including MRSA) may be less expensive than antibiotic treatment, R.Miedzybrodzki, W. Fortuna, B.Weber-Dąbrowska, A.Górski, Adv.Hyg.Exp.Med. 2007,61,461-465,
    http://www.phmd.pl/modules.php?name=Current_Issue&d_op=summary&id=10883
  27. Bacteriophages in medicine, Andrzej Górski , Jan Borysowski, Ryszard Międzybrodzki, Beata-Weber-Dąbrowska, In: S. McGrath, D. van Sinderen (Eds), Bacteriophage: Genetics and Molecular Biology. Caister Academic Press, 2007, pp. 125-158.
  28. Hoc protein regulates the biological effects of T4 phage in mammals, K.Dąbrowska, M.Zembala, J.Boratyński, K.Świtała-Jeleń, J.Wietrzyk, A.Opolski, K.Szczaurska, M.Kujawa, J.Godlewska, A.Górski, Arch Microbiol. 2007,187,489-98
  29. Befsztyki doprawione wirusem,
    Stany Zjednoczone właśnie postanowiły dodawać do żywności bakteriofagi, dobroczynne wirusy, które stają się konkurencją dla antybiotyków.
  30. Terapia fagowa jako alternatywa w leczeniu zakażeń wywołanych przez bakterie antybiotykooporne, R.Międzybrodzki, J.Borysowski, W.Fortuna, B.Weber-Dąbrowska, A.Górski, Kardiochir. Torakochir. Pol. 2006,3,201-205
  31. Successful eradication of methicillin-resistant Staphylococcus aureus (MRSA) carrier status in a healthcare worker, P.Leszczyński, B.Weber-Dąbrowska, M. Kohutnicka, M.Łuczak, A. Górecki, A. Górski, Folia Microbiol. 2006,51,236-8
  32. Experimental phage therapy in humans as seen from a medical, legal, and administrative perspective, A.Górski, R.Międzybrodzki, B.Weber-Dąbrowska, W.Fortuna, J.Borysowski, 1st Texas/Evergreen Phage/Virus Genomics and Ecology Meeting, Kingsville, TX, USA, 12-16 May 2006. Abstracts, p.12.
  33. Effects of bacteriophages on free radical production and phagocytic functions, Anna Przerwa, Michał Zimecki, Kinga Świtała-Jeleń, Krystyna Dąbrowska, Ewa Krawczyk, Mirosław Łuczak, Beata Weber-Dąbrowska, Danuta Syper, Ryszard Międzybrodzki, Andrzej Górski, Med Microbiol Immunol, 2006,31, 1-8
    http://dx.doi.org/10.1007/s00430-006-0011-4
  34. Bacteriophage endolysins as a novel class of antibacterial agents, J.Borysowski, B.Weber-Dąbrowska, A.Górski, Exp Biol Med, 2006,231,366-77
  35. Bacteriophage translocation, Andrzej Gorski, Ewa Wazna, Beata Weber-Dąbrowska, Krystyna Dąbrowska, Kinga Świtała-Jeleń, Ryszard Międzybrodzki, FEMS Immunology & Medical Microbiology, 2006,46,313-9.
  36. Possible association between phages, Hoc protein, and the immune system, Krystyna Dąbrowska, Kinga Świtała-Jeleń, Adam Opolski, Andrzej Górski, Arch Virol, 2006,151,209-215
  37. Bacteriophages and transplantation tolerance, A.Górski, M.Kniotek, A.Perkowska-Ptasińska, A.Mróz, A.Przerwa, W.Gorczyca, K.Dąbrowska, B.Weber-Dąbrowska, M.Nowaczyk, Transplantation Proc., 2006,38,331-3
  38. Activity of bacteriophages in murine tumour models depends on the route of phage administration, K. Dąbrowska, A. Opolski, J. Wietrzyk, D. Nevozhay, K. Szczaurska, K. Świtala-Jeleń, J. Boratyński, A. Górski, Oncology Research, 2005,15,183-187
  39. Potencjalne zastosowania bakteriofagów w świetle obecnego kryzysu antybiotykoterapii,
    The potential use of bacteriophages in view of the current antibiotic therapy crisis    ,
    J. Borysowski, B. Weber-Dąbrowska, A. Górski, Pol Arch Int Med 2005,113, 73-8 (in Polish)
  40. Bacterial viruses against viruses pathogenic for man?, R. Międzybrodzki, W. Fortuna, B. Weber-Dąbrowska, A. Górski, Virus Research, 2005,110,1-8
  41. The potential role of endogenous bacteriophages in controlling invading pathogens, A. Górski, B. Weber-Dąbrowska, Cell. Mol. Life Sci., 2005,62,511-519
  42. Bakteriofagi a kryzys antybiotykoterapii, A. Górski, B. Weber-Dąbrowska, J. Borysowski, Medycyna po Dyplomie, 2004, suppl. 21/04, 3-4
  43. Antitumour activity of bacteriophages in murine experimental cancer models caused possibly by inhibition of ß3 integrin signaling pathway, K. Dabrowska, A. Opolski, J. Wietrzyk, K. Switala-Jelen, J. Boratynski, A. Nasulewicz, L. Lipinska, A. Chybicka, M. Kujawa, M. Zabel, B. Dolinska-Krajewska, E. Piasecki, B. Weber-Dabrowska, J. Rybka, J. Salwa, E. Wojdat, M. Nowaczyk, A. Gorski, Acta Virologica, 2004, 48, 241-248
  44. Anticancer activity of bacteriophage T4 and its mutant HAP1 in mouse experimental tumour models, K.Dąbrowska, A.Opolski, J. Wietrzyk, K.Świtała-Jeleń, J.Godlewska, J.Boratyński, D.Syper, B.Weber-Dąbrowska, A.Górski,
    Anticancer Research, 24(6):3991-3995, 2004
  45. Clinical phage therapy: present and future, A. Gorski, B. Weber-Dabrowska, K. Dabrowska, A. Opolski, R. Miedzybrodzki, K. Switala-Jelen, J. Boratynski, M. Nowaczyk, M. Kniotek, P. Wierzbicki,
    American Society for Microbiology Conference on the New Phage Biology, August, 2004, Key Biscayne, USA
  46. Bacteriophage interactions with T cells and platelets, M. Kniotek, AMA Ahmed, K. Dąbrowska, K. Świtała-Jeleń, A. Opolski, A. Górski,
    In: Cytokine Network, Regulatory Cells, Signalling, and Apoptosis (Immunology 2004), p. 189
    Monduzzi Editors, Bologna, Italy.
  47. Phages as Immunomodulators of Antibody Production, M. Kniotek, B. Weber-Dąbrowska, K. Dąbrowska, K. Świtała-Jeleń, J. Boratyński, M. Wiszniowski, W. Glinkowski, I. Babiak, A. Górecki, M. Nowaczyk, A. Górski,
    In: Genomic Issues, Immune System Activation and Allergy (Immunology 2004), p. 33
    Monduzzi Editors, Bologna, Italy.
  48. Perspectives of bacteriophage therapy in urology, A. Gorski, B. Weber-Dabrowska, R. Miedzybrodzki, W. Fortuna, R. Hanecki, Urological Review, 2004,5,8-10 (in Polish)
  49. Bacteriophage penetration in vertebrates, Krystyna Dabrowska, Kinga Switala-Jelen, Beata Weber-Dabrowska, Andrzej Gorski, J. Appl. Microbiol., 2005,98,7-13
  50. Preparation of endotoxin-free bacteriophages, J. Boratyński, D. Syper, B. Weber-Dąbrowska, M. Łusiak-Szelachowska, G. Późniak, A. Górski, Cellular & Molecular Biology Letters, 2004,9,253-259
  51. New insights into the possible role of bacteriophages in transplantation, A.Górski, M.Nowaczyk, B.Weber-Dąbrowska, M.Kniotek, J.Boratyński, A.Ahmed, K.Dąbrowska, P.Wierzbicki, K.Świtała-Jeleń, A.Opolski, Transplantation Proc. 2003,35,2372-2373
  52. Bacteriophages provide regulatory signals in mitogen-induced murine splenocyte proliferation, Michał Zimecki, Beata Weber-Dąbrowska, Marzanna Łusiak-Szelachowska, Marian Mulczyk, Janusz Boratyński, Gryzelda Poźniak, Danuta Syper, Andrzej Górski, Cellular & Molecular Biology Letters, 2003,8,699–711
  53. Ludwik Hirszfeld, Walka świata niewidzialnego z pozawidzialnym, (The battle of the invisible with the imperceptible)
  54. Computer simulations of phage therapy, A. Zwiefka, B. Weber-Dąbrowska, A. Górski, Adv. Clin. Exp. Med. 2003,12,105-109 (in Polish)
  55. Bacteriophages as an efficient therapy for antibiotic - resistant septicemia in man, Beata Weber-Dabrowska, Marian Mulczyk, Andrzej Górski, Transplantation Proc. 2003,35,1385-1386
  56. New insights into the possible role of bacteriophages in host defense and disease, Andrzej Gorski, Krystyna Dabrowska, Kinga Switala-Jelen, Maria Nowaczyk, Beata Weber-Dabrowska, Janusz Boratynski, Joanna Wietrzyk, Adam Opolski, Medical Immunology 2003, 2:2
  57. Effect of phage therapy on the turnover and function of peripheral neutrophils, B. Weber-Dąbrowska, M. Zimecki, M. Mulczyk, A. Górski, FEMS Immunology and Medical Microbiology, 2002, 34, 135-138
  58. Bacteriophage Inhibits Metastasis in Mouse Transplantable Melanoma Model, Andrzej Gorski, Krystyna Dabrowska, Joanna Wietrzyk, Anna Nasulewicz, Adam Opolski, American Association for Cancer Research: An AACR Special Conference in Cancer Research “Proteases, Extracellular Matrix, and Cancer” 9-13.10.2002 Hilton Head Island, USA, Conference Proceedings: Abstracts of Poster Presentation n. B33
  59. Mutations in bacteriophage T4 genome, K. Świtała-Jeleń, K. Dąbrowska, A. Górski, L. Śliwa, Acta virologica, 2002, 46, 57-62
  60. Therapy of infections in cancer patients with bacteriophages, B. Weber-Dąbrowska, M. Mulczyk, A. Górski, Clin Appl Immunol Rev, 2001, 1, 131
  61. Bacteriophage therapy of bacterial infections: an update of our Institute`s experience, B. Weber-Dąbrowska, M. Mulczyk, A. Górski, Arch. Immunol. Ther. Exp., 2000, 48, 547
  62. Results of bacteriophage treatment of suppurative bacterial infections in the years 1981 - 1986, S. Ślopek, B. Weber-Dąbrowska, M. Dąbrowski, A. Kucharewicz-Krukowska, Arch. Immunol. Ther. Exp., 1987, 35, 569
  63. Results of bacteriophage treatment of suppurative bacterial infections: General Evaluation of the Results, S. Ślopek, I. Durlakowa, B. Weber-Dąbrowska, A. Kucharewicz-Krukowska, M. Dąbrowski, R. Bisikiewicz, Arch. Immunol. Ther. Exp., 1983, 31, 267
  64. Ludwik Hirszfeld, Bakteriofagi i ich rola w rozpoznawaniu duru brzusznego, (Bacteriophages and their role in the diagnosis of typhoid fever)
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